Clinical → Commercial Translation

Turn clinical evidence
into commercial clarity.

I help life sciences teams turn trial data, competitor evidence and complex clinical evidence into sharper positioning, clearer messaging and better commercial decisions.

For teams preparing for launch, reacting to new data, pressure-testing a story, or aligning medical, market access, commercial and leadership around what the evidence really means.

NewInteractive assessment

Product Positioning Health Check

How well aligned is your commercial positioning with the evidence behind it?

Answer eight questions about your own pharmaceutical product and receive a tailored assessment of how your clinical evidence, commercial positioning and adoption priorities fit together, including areas that may benefit from further investigation.

Around 5 minutes · No product names required · No sign-in

Jack Kohler

Jack Kohler

Commercial Strategy · Life Sciences

LinkedIn

About

Built from experience, not theory.

This work comes from more than a decade in pharma commercial roles across sales, marketing, brand strategy and international markets. The same issue kept appearing: strong clinical evidence, experienced teams, and still a difficult question, what should actually be carried forward into the commercial decision?

The challenge is rarely the evidence alone. It is how that evidence is interpreted, prioritised and reshaped as it moves between clinical, medical, market access, regulatory, agency and commercial teams.

10+ years life sciences commercial strategyPharma, biotech and international marketsEvidence interpretation, positioning and launch thinking

"The breakdown is rarely the data. It is what gets interpreted, prioritised, and carried forward."

Bring me in when

The data is clear, but the decision is not.

These are the moments where clinical evidence needs to become a sharper commercial read before teams lock in positioning, messaging or strategic direction.

A readout needs a commercial read

The result is positive, but the commercial implication is not yet clear.

The position is becoming too broad

The evidence supports a direction, but the story is defaulting to a general efficacy message.

Interpretation is not aligned

Medical, market access, commercial and leadership are taking different meanings from the same evidence.

A competitor move has shifted the context

New data or a market announcement has created uncertainty about the real commercial threat.

The positioning has not been pressure-tested

The story sounds right internally, but has not yet been tested against stakeholder questions, field use, access rationale or leadership scrutiny.

Leadership needs a sharper recommendation

The team needs a clearer direction for launch planning, investment decisions, investor updates or cross-functional alignment.

How I can help

Three ways teams typically engage.

Evidence

Clinical Evidence Translation Audit

Best for

Teams with new data and an unclear commercial read before direction is locked.

What you get

  • →A structured read of what the evidence supports, what it does not, and where the commercial risk sits
  • →Commercial implications mapped to the decision at hand
  • →Clear view of where the story needs pressure-testing
Positioning

Positioning Pressure Test

Best for

Teams preparing a positioning story for launch planning, leadership discussion or wider internal review.

What you get

  • →An honest commercial assessment of whether the positioning is clear, credible and defensible
  • →Identification of where the story is too broad, too technical or not differentiated enough
  • →Practical direction on what to sharpen before the story is taken into wider decision-making
Try the free Health Check →
Narrative

Commercial Messaging Review

Best for

Teams that need a clearer story for launch, leadership or investor discussion.

What you get

  • →A clearer commercial story grounded in the evidence
  • →Stakeholder-specific messaging direction
  • →Recommendations on what to say, what not to say, and what still needs work
Book a 20-minute conversation

Not sure which fits? Start with a conversation.

What this looks like in practice

From readout to
commercial decision.

Open an illustrative scenario showing how a broad positive result is pressure-tested into a focused commercial position, including what to lead with, what to qualify and what to leave behind.

What you get

Decision-ready outputs,
not another framework deck.

Each engagement is designed to leave the team with a clearer commercial read, sharper choices and practical recommendations they can act on.

  • Evidence readout interpretation
  • Clear positioning implications
  • Messaging direction grounded in the evidence
  • Competitor implications and response options
  • Stakeholder-specific narrative
  • Leadership-ready summary
  • Clear recommendations on what to say, what not to say, and where the story needs more pressure-testing

Built for Expert Teams

Designed to support specialist judgement

A human-led advisory approach that helps teams pressure-test what evidence can credibly support before strategy, messaging or investment decisions become harder to change.

Human-led

A structured advisory methodology, not an automated decision tool. Outputs are shaped by evidence review and commercial judgement.

Supports expert teams

Designed to connect clinical, medical, market access and commercial perspectives. Specialist review stays with the right internal experts.

Confidentiality & AI use

Client confidential materials are handled under appropriate agreement and are not entered into external AI systems without explicit approval.

Clinical to Commercial Translation is an independent advisory practice. Work is based on public-domain evidence, client-provided materials and professional experience. It does not use confidential information or intellectual property from any former employer or third party.

Next Step

Pressure-test your evidence story.

A focused review of the evidence, the position, and where the story is likely to hold or be exposed.

For teams approaching a data readout, launch, board discussion, market access decision or strategic inflection point.